Mutations in genes encoding proteins that regulate chromatin structure are one of the most frequent causes of neurodevelopmental disorders, like Autism and Intellectual Disability. We have very limited knowledge about how disrupted chromatin regulation can impact brain function. The main goals of the Kramer lab are: 1) To understand the role of epigenetics and chromatin in regulation of learning and memory. 2) To reveal the disease mechanisms underlying neurodevelopmental disorders that are caused by disrupted chromatin regulation.